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Cell. 1994 Dec 16;79(6):1025-34.

The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor.

Author information

1
Department of Pediatrics, Stanford University, California 94305.

Abstract

The mouse kreisler (kr) mutation causes segmentation abnormalities in the caudal hindbrain and defective inner ear development. Based on an inversion discovered in the original kr allele, we selected a candidate cDNA highly expressed in the developing caudal hindbrain. This cDNA encodes a basic domain-leucine zipper (bZIP) transcription factor and was confirmed to represent the kr gene by analysis of a second kr allele, generated by chemical mutagenesis, in which a serine is substituted for an asparagine residue conserved in the DNA-binding domain of all known bZIP family members. The identity, expression, and mutant phenotype of kr indicate an early role in axial patterning and provide insights into the molecular and embryologic mechanisms that govern hindbrain and otic development.

PMID:
8001130
DOI:
10.1016/0092-8674(94)90033-7
[Indexed for MEDLINE]

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