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Br J Obstet Gynaecol. 1994 Oct;101(10):888-93.

Serum albumin and CA125 are powerful predictors of survival in epithelial ovarian cancer.

Author information

1
Clinical Oncology Unit, Bradford University, West Yorkshire, UK.

Abstract

OBJECTIVE:

To assess the prognostic significance of presentation serum albumin, clinical stage and CA125 levels in ovarian cancer.

DESIGN:

Retrospective analysis of data using a Cox proportional hazards model.

SETTING:

A district general hospital oncology unit.

SUBJECTS:

One hundred and fourteen consecutive patients with epithelial ovarian cancer.

INTERVENTIONS:

Cytotoxic chemotherapy and surgery.

MAIN OUTCOME MEASURE:

Survival.

RESULTS:

A linear increase in risk was observed with high log CA125 (P < 0.0001) and with low albumin (P < 0.0001). In late stage patients (III and IV) albumin is the best predictor of survival (P = 0.0006). The presence of ascites, blood transfusion, type of surgery or chemotherapy did not improve the predictive model.

CONCLUSIONS:

CA125 and albumin can be used to identify prognostic subgroups independently of stage. Albumin alone can also be used as a predictor of survival. A simple classification of patients into three groups based on serum albumin of 41 g/l or more, 35 to 40 g/l and 34 g/l or less provides a clear separation of survival curves in the present group of patients.

[Indexed for MEDLINE]

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