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Biochem Biophys Res Commun. 1994 Nov 30;205(1):73-8.

c-erbB-2 gene product associates with catenins in human cancer cells.

Author information

1
Pathology Division, National Cancer Center Research Institute, Tokyo, Japan.

Abstract

Phosphorylation of beta-catenin, an intracytoplasmic cadherin-binding protein, causes disruption of the cadherin-mediated cell adhesion system in cancer cells. A 185-kDa phosphorylated protein, identified as the c-erbB-2 gene product, was co-immunoprecipitated with the E-cadherin-catenin complex. Association of the c-erbB-2 gene product with the cadherin-catenin complex was proven to be mediated through beta-catenin and plakoglobin using an in vitro protein-protein precipitation system. These results indicate that the c-erbB-2 gene product associates with catenins and may regulate the cell adhesion and invasive growth of cancer.

PMID:
7999105
DOI:
10.1006/bbrc.1994.2631
[Indexed for MEDLINE]

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