Abstract
The efficacy of a long-term transfusion regimen in preventing sickle cell disease complications is unknown. We examined 17 patients before, during, and after transfusion for cerebral vascular accident and vaso-occlusive crisis. Total hospitalization rate, as well as admissions for vaso-occlusive crisis, cases of acute chest syndrome, and bacterial infections decreased while patients were on a transfusion regimen.
Publication types
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Clinical Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Anemia, Sickle Cell / complications
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Anemia, Sickle Cell / therapy*
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Bacterial Infections / epidemiology
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Bacterial Infections / etiology
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Bacterial Infections / prevention & control*
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Blood Transfusion*
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Cerebrovascular Disorders / epidemiology
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Cerebrovascular Disorders / etiology
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Cerebrovascular Disorders / prevention & control*
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Chest Pain / epidemiology
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Chest Pain / etiology
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Chest Pain / prevention & control*
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Child
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Child, Preschool
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Hospitalization / statistics & numerical data
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Humans
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Syndrome
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Time Factors
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Treatment Outcome
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Virus Diseases / epidemiology
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Virus Diseases / etiology
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Virus Diseases / prevention & control*