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Clin Pharmacol Ther. 1994 Dec;56(6 Pt 2):768-73.

Amphetamine-like effect of l-deprenyl (selegiline) in drug discrimination studies.

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Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Medical School, Baltimore.


l-Deprenyl has dose-dependent amphetamine- and methamphetamine-like discriminative stimulus properties in rats and monkeys. However, these actions occur only at doses that are well above the clinically relevant dose range for l-deprenyl and are likely to reflect its metabolic conversion to amphetamine products. In view of its weak potency for producing amphetamine-like effects and their slow onset, it may not be surprising that l-deprenyl does not appear to have amphetamine-like abuse potential and has been used therapeutically in the treatment of Parkinson syndrome for more than 20 years with no reported instances of abuse.

[Indexed for MEDLINE]

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