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Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11934-7.

Initiation of meiotic recombination is independent of interhomologue interactions.

Author information

1
Institute of Molecular Biology, University of Oregon, Eugene 97403-1229.

Abstract

In yeast meiosis, crossing-over between homologues is dependent upon double-strand breaks. We demonstrate that the occurrence of these breaks is independent of pairing between homologues by showing that they occur with normal frequency, timing, and position in the absence of a homologue. This observation supports models that view double-strand breaks as initiating events and crossing-over as a consequence of repair of these breaks.

PMID:
7991560
PMCID:
PMC45350
[Indexed for MEDLINE]
Free PMC Article

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