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Nature. 1994 Dec 8;372(6506):519-24.

Long-term synapse loss induced by focal blockade of postsynaptic receptors.

Author information

1
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110.

Abstract

Focal application in vivo of alpha-bungarotoxin to block neurotransmission in a small region of a neuromuscular junction causes long-lasting synapse elimination at that site. In contrast, blockade of neurotransmission throughout a junction does not cause synapse elimination. These and related experiments indicate that active synaptic sites can destabilize inactive synapses in their vicinity.

PMID:
7990923
DOI:
10.1038/372519a0
[Indexed for MEDLINE]

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