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FEBS Lett. 1994 Dec 5;355(3):247-50.

Expression of cytochrome P-450 3A in HT29-MTX cells and Caco-2 clone TC7.

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Unité de Recherches de Biochimie Pharmacologique et Métabolique (INSERM U75), Centre Hospitalo-Universitaire Necker-Enfants Malades, Paris, France.

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  • FEBS Lett 1995 Mar 27;362(1):99.


HT-29 sublines and Caco-2 clones were analyzed for the expression of cytochrome P-450 3A. The enzyme was found to be expressed in differentiated HT-29 cells selected by resistance to methotrexate and in one of seven Caco-2 clones, TC7. Its expression parallels the differentiation process, with highest levels being observed at late confluency. P-450 3A mRNA and protein patterns, as well as subcellular distribution, are intermediate between those observed in human adult intestine and fetal liver.

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