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Curr Opin Cell Biol. 1994 Aug;6(4):527-32.

ARF: a key regulatory switch in membrane traffic and organelle structure.

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Cell Biology & Metabolism Branch, NICHD, National Institutes of Health, Bethesda, MD 20892.


The small GTP-binding protein ADP ribosylation factor (ARF) regulates, through a GTP cycle, the reversible binding of cytosolic coat proteins to Golgi membranes. By determining the binding and release of coat proteins from membranes, ARF controls the production and lifetime of coated-membrane structures. In the past year, studies suggesting a role for ARF in phospholipid metabolism have broadened our perspective on ARF function within the cell.

[Indexed for MEDLINE]

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