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Yeast. 1994 Jul;10(7):935-44.

The peroxisomal targeting signal of 3-oxoacyl-CoA thiolase from Saccharomyces cerevisiae.

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Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021.


All peroxisomal 3-oxoacyl-CoA thiolases identified so far do not contain the previously identified tripeptide peroxisomal targeting signal at their carboxy-termini. For the two rat thiolases it was shown that their peroxisomal targeting signals are localized within the amino-terminal region of the proteins and are cleaved upon import. This report demonstrates that the N-terminal region of the peroxisomal 3-oxoacyl-CoA thiolase from Saccharomyces cerevisiae is essential for its peroxisomal targeting, and that the N-terminal 16 amino acids of yeast thiolase are sufficient to target the otherwise cytosolic small subunit of ribulose-1,5-bisphosphate carboxylase to peroxisomes for import.

[Indexed for MEDLINE]

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