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Nat Genet. 1993 Apr;3(4):358-64.

HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families.

Author information

1
Department of Human Genetics, Roche Molecular Systems, Inc., Alameda, California 94501.

Abstract

The role of HLA class II alleles in genetic predisposition to insulin dependent diabetes mellitus (IDDM) was examined by PCR/oligonucleotide probe typing of 42 Mexican-American IDDM families derived from Hispanic Caucasians and Native Americans. All high risk haplotypes (HLA-DR3 and DR4) were of European origin while the most strongly protective haplotype (DRB1*1402) was Native American. Of the 16 DR-DQ DR4 haplotypes identified, only those bearing DQB1*0302 conferred risk; the DRB1 allele, however, also markedly influenced IDDM risk. The general pattern of neutral and protective haplotypes indicates that the presence of Asp-57 in the HLA-DQ beta chain does not confer IDDM protection per se and indicates that both DRB1 and DQB1 influence IDDM susceptibility as well as protection.

PMID:
7981758
DOI:
10.1038/ng0493-358
[Indexed for MEDLINE]

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