Hormonal regulation of hypothalamic gene expression: identification of multiple novel estrogen induced genes

J Steroid Biochem Mol Biol. 1994 Nov;51(3-4):131-6. doi: 10.1016/0960-0760(94)90085-x.

Abstract

Estrogen (E) has been shown to play a major role in hypothalamic function and is a prerequisite for progesterone (P) induced sexual behavior in female rats. In the course of studies in search of steroid induced hypothalamic genes, we discovered a surprisingly large number of E-induced genes (21 mRNAs in total). This is the largest number of E-induced genes ever identified in a single organ. Many of these mRNAs exhibit considerable magnitudes of induction and their levels were maintained typically during subsequent P treatment. Among the induced genes, several encode metabolic enzymes and may account for some of the morphological changes observed in hypothalamic neurons in response to E. Since E appears to play a major role in defining the pattern of hypothalamic gene expression in conjunction with its capacity for behavioral modulation, these newly identified cDNAs may serve as genetic markers for correlative studies of E-induced central nervous system behavior.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • DNA, Complementary / genetics
  • Estradiol / analogs & derivatives*
  • Estradiol / pharmacology
  • Female
  • Gene Expression Regulation / drug effects*
  • Genetic Markers
  • Hypothalamus / drug effects*
  • Hypothalamus / physiology*
  • Molecular Sequence Data
  • Progesterone / pharmacology
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Sexual Behavior, Animal / drug effects
  • Sexual Behavior, Animal / physiology

Substances

  • DNA, Complementary
  • Genetic Markers
  • RNA, Messenger
  • Progesterone
  • Estradiol
  • estradiol-17 beta-benzoate

Associated data

  • GENBANK/S74319
  • GENBANK/S74320
  • GENBANK/S74321
  • GENBANK/S74322
  • GENBANK/S74323
  • GENBANK/S74324
  • GENBANK/S74327
  • GENBANK/S74328
  • GENBANK/S74329
  • GENBANK/S74330
  • GENBANK/S74331
  • GENBANK/S74332
  • GENBANK/S74333
  • GENBANK/S74334
  • GENBANK/S74335
  • GENBANK/S74336
  • GENBANK/S74337
  • GENBANK/S74338
  • GENBANK/S74339
  • GENBANK/S74340
  • GENBANK/S74341
  • GENBANK/S74342