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Am J Obstet Gynecol. 1994 Nov;171(5):1273-7.

Interaction between fetal gender and risk factors for fetal growth retardation.

Author information

1
Department of Obstetrics and Gynecology, University of Pavia School of Medicine, Policlinico San Matteo, Italy.

Abstract

OBJECTIVE:

Our purpose was to evaluate the interactions between fetal gender and recognized risk factors of fetal growth retardation.

STUDY DESIGN:

A case-control study of 530 singleton pregnancies complicated by fetal growth retardation and 782 control pregnancies with appropriately grown fetuses was conducted. Interactions were evaluated by logistic regression analysis.

RESULTS:

In logistic regression analysis fetal growth retardation was more frequent in female than male fetuses (odds ratio 1.39, 95% confidence interval 1.06 to 1.82). In female fetuses hypertension-related fetal growth retardation was three times more common than in males. On the other hand, a low (< 50 kg) maternal prepregnancy weight and a low (< 18) body mass index (kg/m2) were significant risk factors for fetal growth retardation in male fetuses only. Although maternal smoking in pregnancy was a significant risk factor for growth retardation in both male and female fetuses, its effect was significantly stronger in male fetuses.

CONCLUSION:

Fetal gender can affect the magnitude of the classic risk factors for fetal growth retardation.

PMID:
7977533
DOI:
10.1016/0002-9378(94)90146-5
[Indexed for MEDLINE]

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