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Am J Med Genet. 1994 Aug 1;52(1):70-4.

FISH detection of Wolf-Hirschhorn syndrome: exclusion of D4F26 as critical site.

Author information

1
Department of OB/GYN, University of South Dakota School of Medicine, Sioux Falls.

Abstract

Wolf-Hirschhorn syndrome (WHS) is due to a deletion in the terminal band of 4p16.3. Among loci that have been involved in deletions are D4S98, D4S95, D4S125, D4F26, as shown by PCR typing, Southern blot hybridization, and/or fluorescent in situ hybridization (FISH). Currently, FISH detection of WHS is predicted upon the deletion of the D4F26 locus with failure to hybridize to pC847.351, a commercially available cosmid probe. A WHS patient is shown to have an interstitial deletion, by hemizygosity at D4S98 and D4S95 but not at D4F26. This suggests that the tip of 4p, specifically D4F26, is not a critical deletion site for WHS.

PMID:
7977466
DOI:
10.1002/ajmg.1320520114
[Indexed for MEDLINE]

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