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Science. 1994 Nov 25;266(5189):1376-80.

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.

Author information

1
Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, MD 20892.

Abstract

GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.

PMID:
7973727
[Indexed for MEDLINE]

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