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Obstet Gynecol. 1994 Dec;84(6):1058-9.

Is penicillin G a better choice than ampicillin for prophylaxis of neonatal group B streptococcal infections?

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University of Rochester School of Medicine and Dentistry, New York.


A review of the pharmacokinetics and the narrow spectrum of action of penicillin G favors this antibiotic over ampicillin for the prophylaxis of early neonatal group B streptococcal (GBS) disease. Penicillin G provides good placental transfer and fetal and neonatal tissue levels. Group B streptococcal disease has a narrower range of sensitivities to penicillin G than to ampicillin, and the potential for selecting more resistant organisms may be greater with the broader spectrum of ampicillin than with penicillin G.

[Indexed for MEDLINE]

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