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Nature. 1994 Nov 24;372(6504):336-43.

Crystal structure at 2.2 A resolution of the MHC-related neonatal Fc receptor.

Author information

1
Division of Biology 156-29, California Institute of Technology, Pasadena 91125.

Abstract

The three-dimensional structure of the rat neonatal Fc receptor (FcRn) is similar to the structure of molecules of the major histocompatibility complex (MHC). The counterpart of the MHC peptide-binding site is closed in FcRn, making the FcRn groove incapable of binding peptides. A dimer of FcRn heterodimers seen in the crystals may represent a receptor dimer that forms when the Fc portion of a single immunoglobulin binds. An alternative use of the MHC fold for immune recognition is indicated by the FcRn and FcRn/Fc co-crystal structures.

PMID:
7969491
DOI:
10.1038/372336a0
[Indexed for MEDLINE]

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