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Nature. 1994 Nov 24;372(6504):333-5.

Gene inhibition using antisense oligodeoxynucleotides.

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1
Gilead Sciences, Foster City, California 94404.

Abstract

Antisense oligodeoxynucleotides (ODNs) have great promise as agents for the specific manipulation of gene expression. Until recently, nonspecific effects of ODNs often confounded the interpretation of antisense studies. Improvements in ODN chemistry and cellular delivery techniques now allow for more potent and specific gene inhibition. This review critically evaluates recent progress in the development of antisense ODNs.

PMID:
7969490
DOI:
10.1038/372333a0
[Indexed for MEDLINE]

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