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Dev Biol. 1994 Oct;165(2):537-44.

M-twist is an inhibitor of muscle differentiation.

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Max-Planck-Institut für Immunbiologie, Freiburg, Germany.


The twist gene encodes a transcription factor containing a conserved basic helix-loop-helix domain. During development, transcription factors of this type are normally associated with the induction of differentiation. Yet the expression pattern of the murine M-twist suggests an inhibitory role during muscle differentiation. Following stable transfection of myogenic mouse cells with an M-twist expression vector, 75% of M-twist-expressing clones were impaired in their ability to differentiate. In contrast, only 15% of control clones were unable to differentiate. Treatment with antisense oligonucleotides restored differentiation capacity in a concentration-dependent manner. Control oligonucleotides had no effect. These experiments show that the mouse twist gene can act as an inhibitor of muscle differentiation and that this inhibition is reversible.

[Indexed for MEDLINE]

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