Format

Send to

Choose Destination
FEBS Lett. 1994 Oct 24;353(3):281-5.

MAP kinase binds to the NH2-terminal activation domain of c-Myc.

Author information

1
Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605.

Abstract

The transcription factor c-Myc is a substrate for phosphorylation by MAP kinases. Here we demonstrate that MAP kinase binds to c-Myc. The NH2-terminal region (residues 1-100) is necessary and sufficient for this interaction. Binding to c-Myc is not dependent on the state of MAP kinase activation. However, the c-Myc/MAP kinase complex is disrupted by ATP. Together, these observations indicate that substrate binding interactions contribute to the specificity of phosphorylation by MAP kinases.

PMID:
7957875
DOI:
10.1016/0014-5793(94)01052-8
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center