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Eur J Pediatr. 1994 Sep;153(9):646-9.

Varicella and thrombotic complications associated with transient protein C and protein S deficiencies in children.

Author information

1
Laboratoire Central d'Hématologie, CHU Robert-Debré, Reims, France.

Abstract

We report six cases of protein S deficiency secondary to varicella. Five cases were complicated by thrombotic and vascular events, namely purpura fulminans and necrotic vasculitis, deep vein thrombosis and stroke. Two cases were associated with protein C deficiency and one case revealed a heterozygous factor XII deficiency. The underlying mechanism of this acquired protein S deficiency is unclear but could be related to a direct effect of zoster virus.

PMID:
7957422
DOI:
10.1007/bf02190684
[Indexed for MEDLINE]

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