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Diabetes Care. 1994 Aug;17(8):832-4.

Maternal glucose tolerance and obstetric complications in pregnancies in which the offspring developed type I diabetes.

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  • 1Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Australia.

Abstract

OBJECTIVE:

To identify possible in utero risk factors in children who develop type I diabetes and to determine the risk of development of type I diabetes in the children of women with gestational diabetes.

RESEARCH DESIGN AND METHODS:

All known children with type I diabetes born at the Mercy Hospital for Women whose mothers had glucose tolerance tests (GTTs) performed during pregnancy were identified. The results of the mothers' GTTs were compared with those of the hospital population, as were their obstetric complications.

RESULTS:

We identified 38 children with type I diabetes born at this hospital whose mothers had GTTs performed during pregnancy. Only one of these mothers had gestational diabetes, compared with 5.6% in the overall hospital population (adjusted odds ratio 0.69, 95% confidence interval 0.12-3.84, P = 0.99). There were no differences in the blood glucose levels between the mothers of the children who developed diabetes and the general hospital population. The birth weights of the children destined to develop diabetes also showed no deviation from the expected distribution, and there were no outstanding features of the mothers' obstetric histories.

CONCLUSIONS:

Maternal blood glucose level is not an important determinant of the child's risk of developing type I diabetes.

PMID:
7956626
[PubMed - indexed for MEDLINE]
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