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Curr Genet. 1994 Jul;26(1):21-30.

Analysis of meiotic recombination events near a recombination hotspot in the yeast Saccharomyces cerevisiae.

Author information

1
Department of Biology, University of North Carolina, Chapel Hill 27599-3280.

Abstract

The region of yeast chromosome III between the HIS4 and LEU2 genes has an unusually high frequency of meiotic recombination. In order to determine the pattern of cross-over and gene conversion events, we constructed a strain with a number of heterozygous markers in this 25-kb interval. We found that very high levels of recombination are localized to regions of DNA near HIS4. In addition, analysis of the patterns of co-conversion of adjacent markers suggests that there is more than one initiation site contributing to recombination of HIS4.

PMID:
7954892
DOI:
10.1007/bf00326300
[Indexed for MEDLINE]

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