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Cell. 1994 Oct 21;79(2):365-75.

Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

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Howard Hughes Medical Institute, Center for Learning and Memory, Cambridge, Massachusetts.


We generated a novel strain of mutant mouse with a deletion in the gene encoding metabotropic glutamate receptor 1 (mGluR1). Gross anatomy of the hippocampus, excitatory synaptic transmission, long-term depression, and short-term potentiation in the hippocampal CA1 region are all apparently normal in the mutant mice. In contrast, long-term potentiation (LTP) is substantially reduced, and a moderate level of impairment is observed in context-specific associative learning. We propose that mGluR1 is not "in line" in LTP production, but rather modulates the plasticity process, and hence affects context-specific associative learning.

[Indexed for MEDLINE]

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