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Brain Res. 1994 Jul 25;652(1):169-73.

Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line.

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  • 1Salk Institute for Biological Research, La Jolla, CA 92037.

Abstract

A neuronal cell line, HT-22, is sensitive to glutamate cytotoxicity via a non-receptor mediated oxidative pathway. 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, blocks this glutamate-induced cell death. Down-regulation of protein kinase C eliminates the protection against glutamate cytotoxicity afforded by TPA. The data suggest that protein kinase C activation blocks an early step in the cytotoxic pathway.

PMID:
7953717
[PubMed - indexed for MEDLINE]
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