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Brain Res. 1994 Jul 11;650(2):341-6.

Single-channel analysis of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons.

Author information

1
Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611.

Abstract

Tetrodotoxin-sensitive and tetrodotoxin-resistant single sodium channel currents were recorded from rat dorsal root ganglion neurons. The two types of sodium channel currents could be distinguished by the effects of predepolarization, 10 nM tetrodotoxin, and the inactivation during depolarization. Single-channel conductances were calculated to be 6.3 and 3.4 pS in the tetrodotoxin-sensitive and tetrodotoxin-resistant channels, respectively.

PMID:
7953703
DOI:
10.1016/0006-8993(94)91803-1
[Indexed for MEDLINE]

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