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Curr Opin Neurol. 1994 Aug;7(4):294-8.

Memory systems in normal and pathological aging.

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  • 1State University of New York at Stony Brook.


Normal memory depends on a number of interdependent systems whose specialized contributions are dissociable at both cognitive and neurobiological levels of analysis. Guided by this multiple systems view of memory, this review provides a selective survey of recent studies on cognitive and neurobiological aging. Taken together, the results suggest that memory decline in human aging partly reflects a compromise of executive memory processes supported by frontal lobe regions of the brain, combined with a deterioration of explicit memory capacities supported by the hippocampal system. Defining how deficits in multiple memory systems interact to account for cognitive aging remains a significant challenge.

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