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Curr Opin Genet Dev. 1994 Aug;4(4):508-16.

Signal transduction and cell fate specification during Caenorhabditis elegans vulval development.

Author information

1
Department of Developmental Biology, Beckman Center, Stanford University Medical Center, California 94305.

Abstract

A receptor tyrosine kinase/Ras signaling pathway controls the specification of vulval cell fates in Caenorhabditis elegans. Recently, C. elegans genes encoding proteins with similarity to mammalian Raf (lin-45), mitogen-activated protein kinase (mpk-1/sur-1), and an HNF-3 transcription factor (lin-31) have been identified and shown to act downstream of let-60 (ras) in this pathway. These genetically identified gene products bridge the gap between signal transduction at the plasma membrane and the control of cell fate specification in the nucleus.

PMID:
7950317
DOI:
10.1016/0959-437x(94)90065-b
[Indexed for MEDLINE]

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