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Br J Dermatol. 1994 Oct;131(4):546-50.

Effect of topical calcipotriol on congenital ichthyoses.

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Department of Dermatology, University Hospital, Nijmegen, The Netherlands.


We investigated the clinical efficacy of topically applied calcipotriol in six patients with congenital ichthyosis, using a double-blind, bilaterally paired, comparative approach. Unilateral improvement, in favour of the calcipotriol-treated side, was observed in three patients with lamellar ichthyosis. A beneficial response was also observed in a patient with bullous ichthyotic erythroderma of Brocq. No clinical side-effects or laboratory anomalies were observed. This study indicates that calcipotriol constitutes a new and promising approach in alleviating disorders of keratinization characterized by hyperproliferation, other than psoriasis.

[Indexed for MEDLINE]

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