Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Immunol. 1994 Aug;6(4):631-5.

The defective gene in X-linked severe combined immunodeficiency encodes a shared interleukin receptor subunit: implications for cytokine pleiotropy and redundancy.

Author information

1
Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Abstract

The interleukin-2 receptor plays a pivotal role in the regulation of the normal T cell immune response to foreign antigen. The IL-2 receptor gamma-chain is one component of this receptor, and is encoded by the gene that is defective in X-linked severe combined immunodeficiency. The clinical manifestations of this disease led to the hypothesis and subsequent confirmation that the gamma-chain was in fact a subunit shared by multiple cytokine receptors, including those for IL-2, IL-4, and IL-7.

PMID:
7946053
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center