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Curr Opin Immunol. 1994 Aug;6(4):545-52.

CD8+ T-cell memory to viruses.

Author information

1
St Jude Children's Research Hospital, Memphis, Tennessee 38101-0318.

Abstract

Recent experiments show that laboratory mice infected once with an influenza A virus or with the murine parainfluenza type 1 virus, called the Sendai virus, have enhanced numbers of cytotoxic T-lymphocyte precursors ( > 20x background) for life. Neither virus persists at the genome level, and the mice are maintained under conditions where there is no possibility of re-infection. These observations are highly relevant to any understanding of CD8+ cell memory and suggest that the clonal burst size associated with the primary challenge is a key determining factor.

PMID:
7946041
DOI:
10.1016/0952-7915(94)90139-2
[Indexed for MEDLINE]

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