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Immunol Today. 1994 Oct;15(10):490-5.

Molecular and functional aspects of PECAM-1/CD31.

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1
Dept of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104.

Abstract

Among vascular cell adhesion molecules, platelet-endothelial cell adhesion molecule (PECAM-1/CD31) has the distinctive feature of being expressed on several of the major cell types associated with the vascular compartment. This makes it uniquely positioned to mediate multiple and important cell-cell interactions involving platelets, leukocytes and endothelial cells. Thus, PECAM-1 may represent a potential target for new therapeutic agents directed at a variety of pathological states.

PMID:
7945775
DOI:
10.1016/0167-5699(94)90195-3
[Indexed for MEDLINE]
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