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Arthritis Rheum. 1994 Oct;37(10):1462-7.

Therapeutic effect of recombinant vaccinia virus expressing the 60-kd heat-shock protein on adjuvant arthritis.

Author information

1
Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.

Abstract

OBJECTIVE:

To analyze the effects of recombinant viruses for 2 heat-shock proteins in the treatment of adjuvant arthritis.

METHODS:

Virus vaccinia recombinant for mycobacterial heat-shock protein 65 (hsp65-VV) and human hsp60 (hsp60-VV) were administered to rats during different stages of adjuvant arthritis. Arthritis score and immunity to the recombinant virus were analyzed.

RESULTS:

When delivered at the pre-arthritis stage, both constructs ameliorated arthritis; greater protection was observed with hsp60-VV. A specific T cell response to the recombinant proteins was detected. Furthermore, hsp60-VV displayed a clear therapeutic effect on established arthritis.

CONCLUSION:

Our results suggest novel avenues of therapeutic intervention in autoimmune arthritis associated with immunity to hsp60.

PMID:
7945471
DOI:
10.1002/art.1780371009
[Indexed for MEDLINE]

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