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Biochem Biophys Res Commun. 1994 Oct 14;204(1):84-90.

Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts.

Author information

1
Laboratory of Molecular Biology, University of Florence, Italy.

Abstract

Overexpression of the apoptosis protection gene bcl-2 abolished the earliest response to serum withdrawal in NIH-3T3 murine fibroblasts, i.e., the abrupt cytoplasmic free calcium drop. This phenomenon, also observed in a myeloid cell line, led us to propose this ionic waving as an early apoptotic signal. Its abolition by bcl-2 overexpression suggests that this gene plays a role also on early events "priming" apoptosis.

PMID:
7945396
DOI:
10.1006/bbrc.1994.2429
[Indexed for MEDLINE]

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