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Ann Neurol. 1994 Oct;36(4):665-7.

Autoantibodies to glutamic acid decarboxylase in palatal myoclonus and epilepsy.

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Department of Neurology, University of Milan, Istituto Scientifico S. Raffaele, Italy.


We report the presence of serum autoantibodies directed against glutamic acid decarboxylase in a patient with epilepsy and palatal myoclonus not associated with brain lesions. Glutamic acid decarboxylase antibody reactivity was dependent on the presence of carboxy-terminal amino acids, similar to that reported in patients with stiff-man syndrome. Marked reduction in the frequency of epileptic attacks and improvement in palatal myoclonus occurred when benzodiazepine was administered and phenytoin was gradually tapered. Testing for anti-glutamic acid decarboxylase antibodies may be indicated in patients with palatal myoclonus and with convulsive disorders refractory to therapy.

[Indexed for MEDLINE]

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