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Am J Obstet Gynecol. 1994 Oct;171(4):984-9.

Normal values of urinary albumin and total protein excretion during pregnancy.

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1
Department of Obstetrics and Gynecology, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200.

Abstract

OBJECTIVE:

Our purpose was to determine the normal 24-hour excretion values of urinary albumin and total protein in healthy pregnant women.

STUDY DESIGN:

We evaluated 270 healthy pregnant women < or = 35 years old without a history of diabetes, hypertension, pyelonephritis, preeclampsia, or renal or connective tissue disease. Adequacy of 24-hour collection was determined by creatinine excretion.

RESULTS:

The mean protein excretion in 24 hours was 116.9 mg, upper 95% confidence limit 259.4 mg. The mean albumin excretion in 24 hours was 11.8 mg, upper 95% confidence limit 28.7 mg. Both protein and albumin excretion increased after 20 weeks of gestation. No patient had evidence of microalbuminuria, defined as urinary albumin excretion > 30 mg/L.

CONCLUSION:

These data support 260 mg per 24 hours of urinary protein and 29 mg per 24 hours of albumin as the upper limit of normal in pregnancy. Albumin accounts for a small fraction of total urinary protein excretion.

PMID:
7943114
[Indexed for MEDLINE]
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