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Mol Microbiol. 1993 Nov;10(4):823-8.

Secondary-sites for integration mediated by the Tn21 integrase.

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Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain.


The integrase encoded by the integron of the transposon Tn21 can mediate the site-specific fusion of two plasmids if there is a recombination hot spot (59 bp element) in one of them and the sequence GWTMW in the other. The use of this latter, loosely defined site explains how antibiotic-resistance genes could first become associated with integrons.

[Indexed for MEDLINE]

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