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J Med Chem. 1994 Sep 30;37(20):3205-11.

"Glycylcyclines". 3. 9-Aminodoxycyclinecarboxamides.

Author information

1
Agricultural Research Division, American Cyanamid Company, Princeton, New Jersey 08543-0400.

Abstract

A series of 9-(acylamino)doxycycline derivatives has been prepared. These analogs exhibit good activity against both tetracycline sensitive and tetracycline resistant Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria that are encoded with the efflux and ribosomal resistance gene factors. N,N-Dialkylglycylamido derivatives possessed the highest activity. Replacement of glycine moiety with other amino acids did not further enhance the activity.

PMID:
7932547
[Indexed for MEDLINE]

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