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J Hepatol. 1994 Jun;20(6):837-41.

Naturally occurring hepatitis B virus mutants with deletions in the core promoter region.

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1
Mayo Clinic, Rochester, MN 55905.

Abstract

A novel class of hepatitis B virus mutants in patients with chronic hepatitis B is described. The predicted effect of the mutations is to disrupt the X open reading frame. The location of the genetic alterations within the putative precore promoter also suggests that they may ameliorate precore transcription, which would provide an alternate mechanism for HBeAg(-) escape variation. Definitive conclusions regarding the effects of these mutations must await additional in vitro and in vivo studies.

PMID:
7930487
[Indexed for MEDLINE]
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