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Int J Immunopharmacol. 1994 May-Jun;16(5-6):425-31.

Monoclonal immunoglobulin deposition disease: a review of immunoglobulin chain alterations.

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Laboratory of Immunology and Immunopathology (CNRS URA 1172, Immunology and Molecular Interactions), Poitiers, France.


Monoclonal immunoglobulin deposition disease, a complication of overtly malignant or apparently benign immunoproliferative disorders, is a severe disease featuring tissue deposition of monoclonal light, light and heavy, or heavy chains. A number of converging arguments strongly suggest a direct pathogenetic role of structural abnormalities or peculiarities of variables regions of light and/or heavy chains (associated with deletions in the constant region for the heavy chains). Recent structural data on these abnormal immunoglobulin chains are reviewed.

[Indexed for MEDLINE]

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