Comparison of two software programs to be used for the calculation of population pharmacokinetic parameters

Int J Biomed Comput. 1994 Jun;36(1-2):143-50. doi: 10.1016/0020-7101(94)90107-4.

Abstract

The pharmacokinetic parameters of apomorphine, a potent dopamine agonist, were calculated after subcutaneous and intranasal administration. Two available software packages for TDM were used (USC*PACK and MW/PHARM). The findings for the calculated parameters Kel, Vslope, Ka and bioavailability were compared. Although small, sometimes significant differences were found, the NPEM program from the USC*PACK collection provides most information about the population under investigation. We found a median Vslope of 1.7408 +/- 0.8461 (S.D.) 1/kg, and a mean Kel of 1.5341 +/- 0.3748 h-1. The absorption after intranasal administration was extremely rapid: Ka = 20.5 +/- 1.96 h-1, comparable with that found with subcutaneous absorption: Ka = 23.04 +/- 2.20 h-1.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Intranasal
  • Adult
  • Aged
  • Apomorphine / administration & dosage
  • Apomorphine / blood
  • Apomorphine / pharmacokinetics*
  • Biological Availability
  • Creatinine / blood
  • Drug Monitoring
  • Drug Therapy, Computer-Assisted
  • Female
  • Humans
  • Injections, Subcutaneous
  • Male
  • Middle Aged
  • Models, Biological*
  • Models, Chemical*
  • Parkinson Disease / drug therapy
  • Software*
  • Tissue Distribution

Substances

  • Creatinine
  • Apomorphine