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Gene. 1994 Sep 30;147(2):301-2.

Cloning of the cDNA encoding rat tissue inhibitor of metalloproteinase 1 (TIMP-1), amino acid comparison with other TIMPs, and gene expression in rat tissues.

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Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.


We have cloned the cDNA encoding the rat tissue inhibitor of metalloproteinase 1 (TIMP-1) from a cDNA library derived from healing skin wounds. The deduced amino acid (aa) sequence shows 66, 35 and 34% identity with human TIMP-1 and TIMP-2, and chicken TIMP-3 aa sequences, respectively. High-level expression of rat TIMP-1 RNA was detected in the skin wounds and in normal ovary.

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