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FEBS Lett. 1994 Sep 26;352(2):171-4.

Expression of TIMP3 mRNA is elevated in retinas affected by simplex retinitis pigmentosa.

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Department of Pharmacology, Rayne Institute, UMDS, Guy's Hospital, London, UK.


To explore the molecular and cellular mechanisms associated with photoreceptor death in retinitis pigmentosa (RP), we have investigated altered transcriptional activity in RP retinas by a differential cDNA screening approach. We identified a clone (K222) showing over-expression in simplex RP retinas compared with controls. K222 encodes a partial cDNA of the human tissue inhibitor of metalloproteinases-3 (TIMP3) gene, a member of a family of genes implicated in extracellular matrix (ECM) remodelling. Increased expression of TIMP3 in degenerating RP retinas may reflect restructuring of the ECM architecture, and disruption of photoreceptor-matrix interactions could contribute to activation of apoptotic cell death processes.

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