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Cell. 1994 Sep 23;78(6):963-72.

Involvement of growth factor receptors in the mammalian UVC response.

Author information

1
Kernforschungszentrum Karlsruhe, Institut für Genetik, Federal Republic of Germany.

Abstract

Irradiation of HeLa cells with short-wavelength ultraviolet light (UVC) induces the modification and activation of the preexisting transcription factors c-Fos-c-Jun (AP-1) and TCF/Elk-1, as well as the protein synthesis independent transcriptional activation of the c-fos and c-jun genes. This response to UVC is mediated via obligatory cytoplasmic signal transduction, involving Ras and Raf, Src, and MAP kinases. The UVC response is inhibited by prior down-modulation of growth factor receptor signaling upon growth factor prestimulation, by suramin (an inhibitor of receptor activation) or by expression of a dominant negative epidermal growth factor (EGF) receptor mutant. These data suggest the involvement of several growth factor receptors in the UVC response. Indeed, UVC induces the suramin-inhibitable immediate tyrosine phosphorylation of the EGF receptor.

PMID:
7923365
DOI:
10.1016/0092-8674(94)90272-0
[Indexed for MEDLINE]

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