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Pediatr Nephrol. 1994 Jun;8(3):343-4.

Clinical observations on the use of the Chinese herb Tripterygium wilfordii Hook for the treatment of nephrotic syndrome.

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Nanjing Medical University, Center of Pediatric Nephrology, People's Republic of China.


A preparation of extracts from the root of the Chinese medicinal herb Tripterygium wilfordii Hook was administered orally at a dose of 1 mg/kg body weight per day to 13 children with idiopathic nephrotic syndrome. Eight children, including 4 who were steroid resistant, went into remission which was maintained in 4 for up to 3 years after withdrawal of treatment. In 3 children the proteinuria lessened with the return of plasma protein concentration to normal, and in 1 child this improvement was maintained for 4 years after treatment ceased. No serious side-effects were noted, but a temporary anti-fertility activity has been noted in other studies of both men and women.

[Indexed for MEDLINE]

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