Format

Send to

Choose Destination
Immunol Today. 1994 Aug;15(8):356-61.

The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases.

Author information

1
Dept of Microbiology-Immunology, Northwestern University Medical School, Chicago, IL 60611.

Abstract

A variety of experimental approaches are currently being evaluated for controlling CD4+ T helper 1 (Th1)-mediated autoimmune pathology. Here, Stephen Miller and William Karpus compare and contrast the efficacies of various antigen-specific regulatory strategies. Particular emphasis is placed on the mechanisms of peripheral immune tolerance and how this may be used in the treatment and analysis of the pathologic T-cell repertoire in autoimmune and virus-induced demyelinating diseases.

PMID:
7916948
DOI:
10.1016/0167-5699(94)90173-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center