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Lung Cancer. 1994 Mar;10 Suppl 1:S91-6.

Modelling the process of drug resistance.

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Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, Canada.


Modelling the process of drug resistance can provide insight into such issues as the difference between intrinsic and acquired drug resistance. Other important biological questions such as whether resistance arises through selective or inducible events can also be addressed by reference to appropriate models. If drug resistant cells are produced by some type of inducible up regulation step then this has a number of qualifications for cancer chemotherapy. Selection theories of drug resistance imply that certain sequences of drugs will be superior to others something which can be tested by experiment.

[Indexed for MEDLINE]

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