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Breast Cancer Res Treat. 1994 Jan;29(1):3-9.

The type I growth factor receptors in human breast cancer.

Author information

1
ICRF Oncology Unit, Hammersmith Hospital, London, U.K.

Abstract

The type 1 family of growth factor receptors includes the EGFR, c-erbB2, c-erbB3, and c-erbB4. All four members of the family are expressed in breast cancer. The EGFR gene and more frequently the c-erbB2 gene are amplified in a proportion of cases. In addition to increased expression as a result of gene amplification, overexpression of perhaps all of the receptors also appears to occur, probably as a result of increased mRNA transcription. Overexpression may have prognostic value and may predict response to current therapies. Finally these GFR proteins represent targets for new types of chemotherapeutic agents.

PMID:
7912566
DOI:
10.1007/bf00666177
[Indexed for MEDLINE]

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