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Curr Opin Immunol. 1994 Apr;6(2):266-72.

Thymocyte lineage commitment: is it instructed or stochastic?

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1
Department of Microbiology and Immunology, University of California, San Francisco 94143-0414.

Abstract

Thymocytes co-expressing the CD4 and CD8 co-receptors differentiate into mature T cells that express either CD4 or CD8 and have helper or cytotoxic functions, respectively. Recent studies indicate that commitment to the CD4+ or CD8+ lineages occurs stochastically, but retention of the appropriate co-receptor is required to complete development.

PMID:
7912080
[Indexed for MEDLINE]
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