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Proc Natl Acad Sci U S A. 1994 May 24;91(11):5109-13.

Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.

Author information

1
Pulmonary Center, Boston University School of Medicine, MA 02118.

Abstract

Lymphocyte chemoattractant factor (LCF) is a lymphocyte cell product that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. In concert with its chemoattractant activity, LCF induces human T-lymphocyte expression of interleukin 2 receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a novel interleukin with no significant homology to any previously described cytokine families. There is an absolute requirement for both autoaggregation of LCF monomers and for membrane-expressed CD4 molecules for LCF-induced migration in lymphocytes.

PMID:
7910967
PMCID:
PMC43941
DOI:
10.1073/pnas.91.11.5109
[Indexed for MEDLINE]
Free PMC Article

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